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Predicted switches in the ELMs Resource


General :OverviewVisualisationStatistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificityCompetitionDomain hidingMotif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : AllosteryPhysicochemical compatibilityPre-translationalDefinedPTM-induced


Specificity - Motif hiding

Motif hiding occurs when there is a large difference in intrinsic affinity of overlapping or adjacent motifs for their respective binding partners, or a large difference in the local abundance of these partners. Binding of an effector to one motif sterically masks the overlapping or adjacent motif, thereby precluding it from binding. Binding of the masking molecule can be PTM-dependent or -independent.

AccessionProteinGeneMotifStartStopVis
P31749RAC-alpha serine/threonine-protein kinaseAKT1LIG_AGCK_PIF_1469474view
P31749RAC-alpha serine/threonine-protein kinaseAKT1LIG_WW_Pin1_4447452view
P07567Gag polyproteingagLIG_WW_1202205view
P07567Gag polyproteingagLIG_PTAP_UEV_1209214view
Q05128Matrix protein VP40VP40LIG_PTAP_UEV_1611view
Q05128Matrix protein VP40VP40LIG_WW_11013view
O73557RING finger protein ZZLIG_WW_19497view
O73557RING finger protein ZZLIG_PTAP_UEV_18085view
P03345Gag polyproteingagLIG_WW_1118121view
P03345Gag polyproteingagLIG_PTAP_UEV_1123128view
P16471Prolactin receptorPRLRLIG_SH2_STAT5342345view
P16471Prolactin receptorPRLRLIG_SCF-TrCP1_1348353view
P06400Retinoblastoma-associated proteinRB1LIG_CYCLIN_1873877view
P06400Retinoblastoma-associated proteinRB1TRG_NLS_Bipartite_1860877view
P06400Retinoblastoma-associated proteinRB1LIG_PP1872878view
P05412Transcription factor AP-1JUNLIG_COP1227234view
P05412Transcription factor AP-1JUNLIG_MAPK_13242view
P05412Transcription factor AP-1JUNLIG_KEPE_3225234view
P05412Transcription factor AP-1JUNLIG_SCF_FBW7_1236243view
P05412Transcription factor AP-1JUNLIG_WW_Pin1_46065view
Q07954Prolow-density lipoprotein receptor-related protein 1LRP1LIG_PTB_Phospho_144674473view
Q07954Prolow-density lipoprotein receptor-related protein 1LRP1LIG_PTB_Phospho_145014507view
Q07954Prolow-density lipoprotein receptor-related protein 1LRP1LIG_PTB_Apo_244674474view
Q07954Prolow-density lipoprotein receptor-related protein 1LRP1LIG_PTB_Apo_245014508view
P05106Integrin beta-3ITGB3LIG_PTB_Phospho_1767773view
P05106Integrin beta-3ITGB3LIG_PTB_Phospho_1779785view
P05106Integrin beta-3ITGB3LIG_PTB_Apo_2767774view
P05106Integrin beta-3ITGB3LIG_PTB_Apo_2779786view
Q99741Cell division control protein 6 homologCDC6LIG_CYCLIN_19498view
Q99741Cell division control protein 6 homologCDC6LIG_APCC_KENbox_28084view
Q9P0K1Disintegrin and metalloproteinase domain-containing protein 22ADAM22LIG_14-3-3_3831836view
Q9P0K1Disintegrin and metalloproteinase domain-containing protein 22ADAM22TRG_ER_diArg_1851854view
Q9P0K1Disintegrin and metalloproteinase domain-containing protein 22ADAM22LIG_14-3-3_3854859view
P05107Integrin beta-2ITGB2LIG_PTB_Apo_2760767view
P05107Integrin beta-2ITGB2LIG_14-3-3_3755760view
P08581Hepatocyte growth factor receptorMETLIG_SH2_SRC13491352view
P08581Hepatocyte growth factor receptorMETLIG_SH2_SRC13561359view
P08581Hepatocyte growth factor receptorMETLIG_SH2_GRB213561359view
Q8R4T5General receptor for phosphoinositides 1-associated scaffold proteinGraspLIG_PDZ_Class_1389394view
P08363Non-structural protein P8S10LIG_PTAP_UEV_14045view
P08363Non-structural protein P8S10LIG_WW_13639view
P69616Protein ORF3NoneLIG_PTAP_UEV_195100view
P69616Protein ORF3NoneLIG_SH3_3102108view
Q06187Tyrosine-protein kinase BTKBTKLIG_SH3_1186192view
Q06187Tyrosine-protein kinase BTKBTKLIG_SH3_1200206view
P05067Amyloid beta A4 proteinAPPLIG_PTB_Apo_2756763view
P05067Amyloid beta A4 proteinAPPLIG_SH2_GRB2757760view
P05067Amyloid beta A4 proteinAPPLIG_WW_Pin1_4740745view
Q8IZP0Abl interactor 1ABI1LIG_SH3_5417421view
Q14118DystroglycanDAG1LIG_WW_1889892view
Q14118DystroglycanDAG1LIG_SH2_SRC892895view
P03230Latent membrane protein 1LMP1LIG_SCF-TrCP1_1210215view
P03230Latent membrane protein 1LMP1LIG_TRAF2_2204209view
P08631Tyrosine-protein kinase HCKHCKLIG_SH3_4248255view
P04233HLA class II histocompatibility antigen gamma chainCD74TRG_LysEnd_APsAcLL_11924view
P04233HLA class II histocompatibility antigen gamma chainCD74TRG_ER_diArg_135view
P04233HLA class II histocompatibility antigen gamma chainCD74LIG_14-3-3_3510view
P09793Cytotoxic T-lymphocyte protein 4Ctla4TRG_ENDOCYTIC_2201204view
P09793Cytotoxic T-lymphocyte protein 4Ctla4LIG_SH2_STAT5201204view
P00533Epidermal growth factor receptorEGFRLIG_SH2_SRC10161019view
P00533Epidermal growth factor receptorEGFRLIG_SH2_SRC11251128view
P00533Epidermal growth factor receptorEGFRTRG_ENDOCYTIC_29981001view
P00533Epidermal growth factor receptorEGFRLIG_PTB_Phospho_111041110view
O88339Epsin-1Epn1LIG_Clathr_ClatBox_1480484view
O88339Epsin-1Epn1LIG_EH_1500504view
P14003Protein hairyhLIG_CtBP_PxDLS_1318322view
P14003Protein hairyhLIG_WRPW_1334337view
Q8TEU7Rap guanine nucleotide exchange factor 6RAPGEF6LIG_PDZ_Class_115961601view
P12931Proto-oncogene tyrosine-protein kinase SrcSRCLIG_SH3_4252259view
P12931Proto-oncogene tyrosine-protein kinase SrcSRCLIG_SH2_SRC530533view
P04637Cellular tumor antigen p53TP53LIG_CYCLIN_1381385view
P04637Cellular tumor antigen p53TP53LIG_MDM21926view
P04637Cellular tumor antigen p53TP53TRG_NES_CRM1_1339352view
P04637Cellular tumor antigen p53TP53LIG_USP7_1359363view
P04637Cellular tumor antigen p53TP53LIG_USP7_1364368view
P04637Cellular tumor antigen p53TP53TRG_NLS_Bipartite_1305323view
P04637Cellular tumor antigen p53TP53LIG_WW_Pin1_43035view
P04637Cellular tumor antigen p53TP53LIG_WW_Pin1_4312317view
P14598Neutrophil cytosol factor 1NCF1LIG_SH3_2363368view
P14598Neutrophil cytosol factor 1NCF1LIG_WW_Pin1_4342347view
Q60787Lymphocyte cytosolic protein 2Lcp2LIG_SH2_SRC145148view
P46527Cyclin-dependent kinase inhibitor 1BCDKN1BLIG_SCF_Skp2-Cks1_1183190view
P46527Cyclin-dependent kinase inhibitor 1BCDKN1BLIG_WW_Pin1_4184189view
P54253Ataxin-1ATXN1LIG_14-3-3_1772777view
P54253Ataxin-1ATXN1LIG_ULM_U2AF65_1770775view
P54253Ataxin-1ATXN1TRG_NLS_MonoCore_2769774view
P25942Tumor necrosis factor receptor superfamily member 5CD40LIG_TRAF6231239view
P25942Tumor necrosis factor receptor superfamily member 5CD40LIG_TRAF2_1250253view
P03322Gag-Pro polyproteingag-proLIG_WW_1172175view
P03322Gag-Pro polyproteingag-proLIG_LYPXL_S_1180184view
P38936Cyclin-dependent kinase inhibitor 1CDKN1ALIG_PCNA_PIPBox_1144153view
P38936Cyclin-dependent kinase inhibitor 1CDKN1ALIG_CRL4_Cdt2_1145157view
P38936Cyclin-dependent kinase inhibitor 1CDKN1ATRG_NLS_Bipartite_1142158view
Q15303Receptor tyrosine-protein kinase erbB-4ERBB4LIG_WW_110531056view
Q15303Receptor tyrosine-protein kinase erbB-4ERBB4LIG_SH2_STAT510561059view
P49755Transmembrane emp24 domain-containing protein 10TMED10TRG_ER_diLys_1215219view
P49755Transmembrane emp24 domain-containing protein 10TMED10TRG_Golgi_diPhe_1204219view
Q06124Tyrosine-protein phosphatase non-receptor type 11PTPN11LIG_SH2_GRB2546549view
P01106Myc proto-oncogene proteinMYCLIG_SCF_FBW7_15562view
P01106Myc proto-oncogene proteinMYCLIG_WW_Pin1_45560view
P01106Myc proto-oncogene proteinMYCLIG_SH3_26065view
P06729T-cell surface antigen CD2CD2LIG_GYF281289view
P06729T-cell surface antigen CD2CD2LIG_GYF295303view
P06729T-cell surface antigen CD2CD2LIG_SH3_3294300view
Q01094Transcription factor E2F1E2F1LIG_CYCLIN_19094view
Q01094Transcription factor E2F1E2F1LIG_HCF-1_HBM_197100view
P03070Large T antigenNoneLIG_Rb_LxCxE_1103107view
P03070Large T antigenNoneTRG_NLS_MonoCore_2127132view
P03070Large T antigenNoneTRG_NLS_MonoExtC_3127133view
P03070Large T antigenNoneTRG_NLS_MonoExtN_4126132view
Q02410Amyloid beta A4 precursor protein-binding family A member 1APBA1LIG_PDZ_Class_2832837view
P51519Envelope glycoproteinenvTRG_ENDOCYTIC_2487490view
P51519Envelope glycoproteinenvTRG_LysEnd_APsAcLL_1463468view
P30307M-phase inducer phosphatase 3CDC25CLIG_14-3-3_3213218view
P30307M-phase inducer phosphatase 3CDC25CLIG_14-3-3_3213218view
P30307M-phase inducer phosphatase 3CDC25CTRG_NES_CRM1_1189203view
Q9U1K1Protein spirespirLIG_Actin_WH2_2432448view
Q9U1K1Protein spirespirLIG_Actin_WH2_1464480view
P29353SHC-transforming protein 1SHC1LIG_SH2_GRB2349352view
P29353SHC-transforming protein 1SHC1LIG_SH2_GRB2427430view
Q9BVK6Transmembrane emp24 domain-containing protein 9TMED9TRG_ER_diLys_1232235view
Q9BVK6Transmembrane emp24 domain-containing protein 9TMED9TRG_Golgi_diPhe_1221235view
O15350Tumor protein p73TP73LIG_SH3_3407413view
O15350Tumor protein p73TP73TRG_NES_CRM1_1366379view
O15350Tumor protein p73TP73TRG_NLS_Bipartite_1327349view
O15350Tumor protein p73TP73LIG_WW_Pin1_4409414view
Q91841Translocon-associated proteinNoneTRG_Golgi_diPhe_1190205view
Q91841Translocon-associated proteinNoneTRG_ER_diLys_1201205view
P06241Tyrosine-protein kinase FynFYNLIG_SH2_SRC531534view
           
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